High glucose levels linked to dementia

Posted by Neill Abayon

Researchers have discovered that those with a high blood sugar level, even if they do not have diabetes, may have an increased risk of developing dementia compared with those who have a normal blood sugar level.

The study, published in the New England Journal of Medicine, analyzed 2,067 participants without dementia aged 65 and over, from a study called Adult Changes in Thought (ACT).

In order to examine the relationship between glucose levels and the risk of dementia, researchers from the University of Washington involved in a Group Health study analyzed average measurements of glycated hemoglobin levels and glucose levels over a period of 6.8 years.

The team compiled specific data from the participants using a Cox regression model - a predictive model that uses time-dependent factors. These included:

Diabetes status

Age

Sex

Study cohort

Educational level

Level of exercise

Blood pressure

Status with respect to coronary/cerebrovascular diseases

Atrial fibrillation

Smoking

Treatment for hypertension.

More here.

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Higher blood sugar levels linked to lower brain function in diabetics

Posted by Neill Abayon

WINSTON-SALEM, N.C. – Results of a recent study conducted by researchers at Wake Forest University Baptist Medical Center and colleagues show that cognitive functioning abilities drop as average blood sugar levels rise in people with type 2 diabetes.

The study appears in this month's issue of Diabetes Care.

The ongoing Memory in Diabetes (MIND) study, a sub-study of the Action to Control Cardiovascular Risk in Diabetes Trial (ACCORD), found a statistically significant inverse relationship between A1C levels (average blood glucose levels over a period of two to three months) and subjects' scores on four cognitive tests. No association, however, was found between daily blood glucose levels (measured by the fasting plasma glucose test) and test scores.

For the study, researchers at 52 of the 77 ACCORD sites throughout the United States and Canada administered a 30-minute battery of cognitive tests to nearly 3,000 individuals ages 55 years and older.

"The tests used in the study measured several aspects of memory function," said Jeff Williamson, M.D., M.H.S., principal investigator for the study at the Wake Forest clinical site. "For example, we tested one's ability to switch back and forth between memory tasks or to 'multitask,' an important skill for people needing to manage their diabetes."

Read the full article here.